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Clinical Trial
. 1997 Sep;158(3 Pt 1):869-71.
doi: 10.1097/00005392-199709000-00050.

Is heparin contraindicated in pelvic lymphadenectomy and radical prostatectomy?

P R Sieber  1 , F M Rommel, V E Agusta, J A Breslin, L E Harpster, H W Huffnagle, C Stahl
Affiliations
Clinical Trial

Is heparin contraindicated in pelvic lymphadenectomy and radical prostatectomy?

P R Sieber et al. J Urol. 1997 Sep.

Abstract

Purpose: We initiated a prospective study to verify or refute the complications of lymphocele formation and excessive blood loss associated with heparin prophylaxis in pelvic lymphadenectomy and radical prostatectomy.

Materials and methods: A prospective study was completed on 579 men undergoing pelvic lymphadenectomy usually in association with radical prostatectomy. Patients were assigned to group 1 (given preoperative and postoperative subcutaneous heparin) and group 2 (no heparin). All patients were evaluated 2 to 3 weeks after surgery with ultrasound for pelvic lymphocele.

Results: There was no statistically significant difference in the number or size of pelvic lymphoceles or blood loss in group 1 versus group 2.

Conclusions: The use of heparin prophylaxis to prevent thromboembolic complications in conjunction with pelvic lymphadenectomy and radical prostatectomy is not associated with increased blood loss or increased rate of lymphocele formation.

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