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. 1977 Dec;91(6):909-13.
doi: 10.1016/s0022-3476(77)80888-3.

Intracranial calcifications in childhood leukemia. An association with systemic chemotherapy

S McIntosh, D B Fischer, S G Rothman, N Rosenfield, J S Lobel, R O'Brien

Intracranial calcifications in childhood leukemia. An association with systemic chemotherapy

S McIntosh et al. J Pediatr. 1977 Dec.

Abstract

Children with acute lymphocytic leukemia were examined for evidence of intracranial calcifications with roentgenograms of the skull and computerized tomography. Of 39 children in their initial complete remission, ten were found to have subcortical cerebral calcifications. Significant associations were found between the presence of cerebral calcifications and systemic treatment with large cumulative doses of methotrexate.

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