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. 1997 Jun;33(3):238-41.
doi: 10.1111/j.1440-1754.1997.tb01587.x.

The prevalence of hepatitis C in survivors of paediatric malignancy

T L Carter  1 , C H Cole, C F Mews, P J Price, D L Baker
Affiliations

The prevalence of hepatitis C in survivors of paediatric malignancy

T L Carter et al. J Paediatr Child Health. 1997 Jun.

Abstract

Objective: To assess the prevalence of hepatitis C in 200 patients with paediatric malignancies, surviving in remission more than 5 years from diagnosis, who had received blood product transfusions before 1990 when routine screening of blood products for hepatitis C began.

Method: The second and third generation Abbott Diagnostics ELISA was used to assess hepatitis C seropositivity. Seropositive patients and those with abnormal liver transaminases were assessed by hepatitis C virus RNA polymerase chain reaction (PCR).

Results: A low incidence (4%) of seropositivity for hepatitis C was found in survivors of paediatric malignancy who were transfused prior to routine screening of blood products in this cohort.

Conclusions: All patients identified have evidence of hepatitis and may be at high risk of developing cirrhosis.

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