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Comparative Study
. 1977 Aug;14(4):256-7.
doi: 10.1136/jmg.14.4.256.

Sister chromatid exchange in dyskeratosis congenita lymphocytes

W Burgdorf, K Kurvink, J Cervenka
Comparative Study

Sister chromatid exchange in dyskeratosis congenita lymphocytes

W Burgdorf et al. J Med Genet. 1977 Aug.

Abstract

Sister chromatid exchange (SCE) frequency in chromosomes from lymphocytes of a patient with dyskeratosis congenita was 12-2 per mitosis. Our 33 normal controls had a mean of 5-4 SCE per mitosis and 5 patients with Fanconi's anaemia averaged 7-6 SCE per mitosis. The rate of chromosome breakage was only 0-5% in the dyskeratosis congenita patient and 0 to 2-5% in controls, while the Fanconi's anaemia patients showed higher values.

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References

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