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. 1997 Sep;71(9):6863-8.
doi: 10.1128/JVI.71.9.6863-6868.1997.

Cryo-electron microscopy structure of yeast Ty retrotransposon virus-like particles

K J Palmer  1 , W Tichelaar, N Myers, N R Burns, S J Butcher, A J Kingsman, S D Fuller, H R Saibil
Affiliations

Cryo-electron microscopy structure of yeast Ty retrotransposon virus-like particles

K J Palmer et al. J Virol. 1997 Sep.

Abstract

The virus-like particles (VLPs) produced by the yeast retrotransposon Ty1 are functionally related to retroviral cores. These particles are unusual in that they have variable radif. A paired mass-radius analysis of VLPs by scanning transmission electron microscopy showed that many of these particles form an icosahedral T-number series. Three-dimensional reconstruction to 38-A resolution from cryo-electron micrographs of T = 3 and T = 4 shells revealed that the single structural protein encoded by the TYA gene assembles into spiky shells from trimeric units.

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