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. 1997 Jul 11;762(1-2):256-8.
doi: 10.1016/s0006-8993(97)00493-9.

N-acetylcysteine protects against age-related increase in oxidized proteins in mouse synaptic mitochondria

M M Banaclocha  1 , A I Hernández, N Martínez, M L Ferrándiz
Affiliations

N-acetylcysteine protects against age-related increase in oxidized proteins in mouse synaptic mitochondria

M M Banaclocha et al. Brain Res. .

Abstract

Since it has been proposed that oxidized protein accumulation plays a critical role in brain aging, we have investigated the effect of a thiolic antioxidant on protein carbonyl content in synaptic mitochondria from female OF-1 mice. At 48 weeks of age, a control group was fed standard food pellets and another group received pellets containing 0.3% (w/w) of N-acetylcysteine. A 24-week treatment resulted in a significant decrease in protein carbonyl content in synaptic mitochondria of the N-acetylcysteine-treated animals as compared to age-matched controls.

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