Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 1997;19(1):57-68.
doi: 10.1007/BF00945025.

Immunopathology of hepatitis C

K M Chang  1 , B Rehermann, F V Chisari
Affiliations
Review

Immunopathology of hepatitis C

K M Chang et al. Springer Semin Immunopathol. 1997.

Abstract

Hepatitis C virus (HCV) infection becomes persistent in the majority of instances in the face of a humoral and cellular immune response, and persistent HCV infection is associated with chronic hepatitis. In particular, cytotoxic T lymphocytes (CTL), crucial in the eradication of virus-infected cells, have been observed in the liver and the peripheral blood of chronically infected patients, suggesting that CTL cannot completely eliminate the virus, and may contribute to chronic liver injury. In this review, the potential host and the viral factors involved in the pathogenesis of chronic HCV infection will be discussed with emphasis on the HLA-A2 restricted peripheral blood CTL response and its relationship to liver disease and viral load.

PubMed Disclaimer

References

    1. JAMA. 1990 Jan 5;263(1):49-53 - PubMed
    1. J Virol. 1996 May;70(5):3307-12 - PubMed
    1. Gut. 1981 Dec;22(12):985-91 - PubMed
    1. J Clin Invest. 1996 Sep 15;98(6):1432-40 - PubMed
    1. Proc Natl Acad Sci U S A. 1989 Apr;86(8):2883-7 - PubMed

Publication types