doi: 10.1046/j.1365-2141.1997.2163033.x.
Frequent involvement of chromosomes 1, 3, 7 and 8 in splenic marginal zone B-cell lymphoma
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- PMID: 9266948
- DOI: 10.1046/j.1365-2141.1997.2163033.x
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Frequent involvement of chromosomes 1, 3, 7 and 8 in splenic marginal zone B-cell lymphoma
Br J Haematol.
1997 Aug.
Abstract
We have studied 19 cases of splenic marginal zone B-cell lymphoma (SMZBCL) combining cytological features, conventional cytogenetics, and in situ hybridization (ISH) techniques. A clonal chromosome abnormality was found in 11/19 patients (58%). The more frequent recurrent abnormalities were: del(3), del (7q), and involvement of chromosomes 1, 3, 7 and 8. No patient showed the translocation t(11;14)(q13;q32). An outstanding finding was the low incidence of trisomy 3 (36%) compared to patients with MALT lymphoma. These findings support the interpretation that SMZBCL is a distinct lymphoproliferative disorder.
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