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Review
. 1997 Aug;22(8):299-306.
doi: 10.1016/s0968-0004(97)01085-2.

Caspases: killer proteases

D W Nicholson  1 , N A Thornberry
Affiliations
Review

Caspases: killer proteases

D W Nicholson et al. Trends Biochem Sci. 1997 Aug.

Abstract

Caspases (cysteinyl aspartate-specific proteinases) mediate highly specific proteolytic cleavage events in dying cells, which collectively manifest the apoptotic phenotype. The key and central role that these enzymes play in a biochemical cell-suicide pathway has been conserved throughout the evolution of multicellular eukaryotes.

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