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. 1997;46(5):410-7.
doi: 10.1007/s002510050295.

HLA class II haplotype and sequence analysis support a role for DQ in narcolepsy

M C Ellis  1 , A H Hetisimer, D A Ruddy, S L Hansen, G S Kronmal, E McClelland, L Quintana, D T Drayna, M S Aldrich, E Mignot
Affiliations
Free article

HLA class II haplotype and sequence analysis support a role for DQ in narcolepsy

M C Ellis et al. Immunogenetics. 1997.
Free article

Abstract

A systematic haplotype and sequencing analysis of the HLA-DR and -DQ region in patients with narcolepsy was performed. Five new (CA)n microsatellite markers were generated and positioned on the physical map across the HLA-DQB1-DQA1-DRB1 interval. Haplotypes for these new markers and the three HLA loci were established using somatic cell hybrids generated from patients. A four-marker haplotype surrounding the DQB1(*)0602 gene was found in all narcolepsy patients, and was identical to haplotypes observed on random chromosomes harboring the DQB1(*)0602 allele. Eighty-six kilobases of contiguous genomic sequence across the region did not reveal new genes, and analysis of this sequence for single nucleotide polymorphisms did not reveal sequence variation among DQB1(*)0602 chromosomes. These results are consistent with other studies, suggesting that the HLA-DQ genes themselves are among the predisposing factors in narcolepsy.

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