Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1976 Aug 1;67(1):123-8.
doi: 10.1111/j.1432-1033.1976.tb10640.x.

Quantitative study of secondary structure of histones H1, H2A, and H4 in solution by infrared spectroscopy

B V Shestopalov, Y N Chirgadze
Free article

Quantitative study of secondary structure of histones H1, H2A, and H4 in solution by infrared spectroscopy

B V Shestopalov et al. Eur J Biochem. .
Free article

Abstract

The secondary structure of histones H1, H2A, and H4 (F1, F2a2, and F2a1) has been quantitatively studied in heavy water (2H2O) solutions in a wide range of histone concentration, p2H, and concentration of sodium chloride using an improved infrared spectroscopy method. Under all conditions there are about 5--10% of alpha helix. Conditions favourable for aggregation induce formation of antiparallel pleated sheet structure to an extent of about 15% in H1 and H2A and about 30% in H4. When the p2H and concentration of NaCl are in the physiological range, there is the same content of this structure in H2A and H4 and none in H1.

PubMed Disclaimer

LinkOut - more resources