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. 1997 Sep;35(9):2220-3.
doi: 10.1128/jcm.35.9.2220-2223.1997.

Immunoreactivity of a 38-kilodalton Penicillium marneffei antigen with human immunodeficiency virus-positive sera

P Chongtrakool  1 , S C Chaiyaroj, V Vithayasai, S Trawatcharegon, R Teanpaisan, S Kalnawakul, S Sirisinha
Affiliations

Immunoreactivity of a 38-kilodalton Penicillium marneffei antigen with human immunodeficiency virus-positive sera

P Chongtrakool et al. J Clin Microbiol. 1997 Sep.

Abstract

Penicillium marneffei produced and secreted a 38-kDa antigen that appeared to be specific for this dimorphic fungus. This component could not be detected in antigenic extracts of Histoplasma capsulatum, Cryptococcus neoformans, Aspergillus niger, Aspergillus fumigatus, Aspergillus flavus, Aspergillus terreus, Candida albicans, and two other species of Penicillium by immunoblot analysis against the sera from patients with culture-confirmed penicilliosis marneffei. Antibody reactive with this antigen was found in a large proportion of human immunodeficiency virus (HIV)-positive patients, indicating a presumptive diagnosis of P. marneffei infection. A small number of asymptomatic HIV-seropositive patients and HIV-seropositive patients with other fungal infections were also found to be positive by this analysis, suggesting that subclinical or mixed fungal infections involving P. marneffei are not uncommon.

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References

    1. J Biol Chem. 1969 Aug 25;244(16):4406-12 - PubMed
    1. J Biol Chem. 1951 Nov;193(1):265-75 - PubMed
    1. Annu Rev Microbiol. 1987;41:209-25 - PubMed
    1. Int J Dermatol. 1992 Jun;31(6):410-2 - PubMed
    1. Eur J Epidemiol. 1993 Jan;9(1):79-85 - PubMed

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