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. 1997 Aug;11(4):287-92.
doi: 10.1006/mcpr.1997.0117.

Combined SSCP/heteroduplex analysis in the screening for PAX6 mutations

R A Axton  1 , I M Hanson, J Love, A Seawright, J Prosser, V van Heyningen
Affiliations

Combined SSCP/heteroduplex analysis in the screening for PAX6 mutations

R A Axton et al. Mol Cell Probes. 1997 Aug.

Abstract

We demonstrate the use of combined SSCP and heteroduplex analysis in the detection of PAX6 mutations using non-radioactive silver staining. A panel of aniridia patients was screened by this approach and we show that a greater number of mutations was detected than would have been found by running each technique alone. Six previously unreported aniridia mutations in PAX6 are also described..

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