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Review
. 1997 Sep 8;138(5):957-60.
doi: 10.1083/jcb.138.5.957.

Motoring to the finish: kinesin and dynein work together to orient the yeast mitotic spindle

T Stearns  1
Affiliations
Review

Motoring to the finish: kinesin and dynein work together to orient the yeast mitotic spindle

T Stearns. J Cell Biol. .
No abstract available

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Figures

Figure 1
Figure 1
Representations of two situations in which spindle orientation is important. In A, the orientation of the mitotic spindle in a cell with an asymmetrically distributed component must change to segregate the component to only one of the two cells after division. The carets indicate the plane of division, based on spindle position. In B, the orientation of the spindle must change to allow for equal segregation of nuclei in an asymmetric cell, such as for budding yeast. The carets indicate the plane of division, based on the predetermined bud site.
See this image and copyright information in PMC

Comment on

References

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    1. Carminati JL, Stearns T. Microtubules orient the mitotic spindle in yeast through dynein-dependent interactions with the cell cortex. J Cell Biol. 1997;138:629–641. - PMC - PubMed
    1. Chenn A, McConnell SK. Cleavage orientation and the asymmetric inheritance of Notch1 immunoreactivity in mammalian neurogenesis. Cell. 1995;82:631–641. - PubMed
    1. Clark SW, Meyer DI. ACT3: a putative centractin homologue in S. cerevisiaeis required for proper orientation of the mitotic spindle. J Cell Biol. 1994;127:129–138. - PMC - PubMed
    1. Cottingham FR, Hoyt MA. Mitotic spindle positioning in Saccharomyces cerevisiaeis accomplished by antagonistically acting microtubule motor proteins. J Cell Biol. 1997;138:1041–1053. - PMC - PubMed

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