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. 1997 Aug;121(8):1507-8.
doi: 10.1038/sj.bjp.0701350.

Evidence for the involvement of P2-purinoceptors in the cholinergic contraction of the guinea-pig ileum

L Barthó  1 , L Lénárd Jr, C A Maggi
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Evidence for the involvement of P2-purinoceptors in the cholinergic contraction of the guinea-pig ileum

L Barthó et al. Br J Pharmacol. 1997 Aug.

Abstract

In the isolated ileum of the guinea-pig the P2-purinoceptor antagonists PPADS and suramin: (a) strongly inhibited the cholinergic contractile effect of alpha,beta-methylene ATP, (b) did not influence contractions evoked by exogenous acetylcholine (ACh) but, (c) moderately (by about 30%) inhibited cholinergic contractions due to electrical field stimulation (EFS), in a non-additive manner. These results suggest that an endogenous ligand that stimulates P2-purinoceptors (possibly ATP) is involved in the contractile effect of EFS, as a positive modulator of ACh release.

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