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. 1997 Sep;179(17):5448-57.
doi: 10.1128/jb.179.17.5448-5457.1997.

An lrp-like gene of Bacillus subtilis involved in branched-chain amino acid transport

B R Belitsky  1 , M C Gustafsson, A L Sonenshein, C Von Wachenfeldt
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An lrp-like gene of Bacillus subtilis involved in branched-chain amino acid transport

B R Belitsky et al. J Bacteriol. 1997 Sep.

Abstract

The azlB locus of Bacillus subtilis was defined previously by a mutation conferring resistance to a leucine analog, 4-azaleucine (J. B. Ward, Jr., and S. A. Zahler, J. Bacteriol. 116:727-735, 1973). In this report, azlB is shown to be the first gene of an operon apparently involved in branched-chain amino acid transport. The product of the azlB gene is an Lrp-like protein that negatively regulates expression of the azlBCDEF operon. Resistance to 4-azaleucine in azlB mutants is due to overproduction of AzlC and AzlD, two novel hydrophobic proteins.

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