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Review
. 1997 Aug;9(4):563-7.
doi: 10.1016/s0952-7915(97)80111-2.

Role of dendritic and follicular dendritic cells in HIV infection and pathogenesis

G Grouard  1 , E A Clark
Affiliations
Review

Role of dendritic and follicular dendritic cells in HIV infection and pathogenesis

G Grouard et al. Curr Opin Immunol. 1997 Aug.

Abstract

Dendritic cells (DCs) and follicular dendritic cells (FDCs) play important roles in HIV-mediated pathogenesis. Recent studies have defined new DC subsets and shown that DCs in lymphoid mucosa can both harbor virus and stimulate its spread into CD4(+) T cells. FDCs harbor unspliced HIV mRNA and immune complexed virus, but not actively infectious virus, yet these cells are a key regulated reservoir of virions.

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