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. 1977 Dec 16;198(4322):1162-3.
doi: 10.1126/science.929193.

Polymorphonuclear leukocytes: possible mechanism of accumulation in psoriasis

G S Lazarus, F J Yost Jr, C A Thomas

Polymorphonuclear leukocytes: possible mechanism of accumulation in psoriasis

G S Lazarus et al. Science. .

Abstract

Extracts of involved and uninvolved skin from nine patients with untreated psoriasis were studied for chemotactic activity. Psoriatic plaque contains increased amounts of a complement-dependent chemotactic factor that is inhibited by diisopropyl fluorophosphate. This factor may be human skin serine proteinase.

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