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Review
. 1997 Sep;18(9):424-7.
doi: 10.1016/s0167-5699(97)01112-2.

Negative signaling in B cells: SHIP Grbs Shc

S Tridandapani  1 , T Kelley, D Cooney, M Pradhan, K M Coggeshall
Affiliations
Review

Negative signaling in B cells: SHIP Grbs Shc

S Tridandapani et al. Immunol Today. 1997 Sep.

Abstract

Negative signaling in B cells is initiated by co-crosslinking of the antigen receptor and the Fcy receptor, resulting in cessation of B-cell signaling events and, in turn, inhibiting B-cell proliferation and antibody secretion. Here, a competitive role is proposed for SHIP in blocking the interaction of Shc with the Grb2-Sos complex of proteins that lead to Ras activation in B cells.

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