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. 1997 Sep 1;80(5):633-4.
doi: 10.1016/s0002-9149(97)00437-2.

Partial reversal of heparin anticoagulation by intravenous protamine in abciximab-treated patients undergoing percutaneous intervention

D J Kereiakes  1 , T M Broderick, D D Whang, L Anderson, D Fye
Affiliations

Partial reversal of heparin anticoagulation by intravenous protamine in abciximab-treated patients undergoing percutaneous intervention

D J Kereiakes et al. Am J Cardiol. .

Abstract

Serious hemorrhage and vascular complications after abciximab therapy are associated with elevated activated clotting time values. Our preliminary experience suggests that low-dose intravenous protamine administration is both safe and effective in reducing elevated in-laboratory activated clotting time values and the potential for serious hemorrhage in abciximab-treated patients.

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