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. 1997 Sep;18(8):1541-7.

Detection of pyramidal tract lesions in amyotrophic lateral sclerosis with magnetization-transfer measurements

Y Kato  1 , K Matsumura, Y Kinosada, Y Narita, S Kuzuhara, T Nakagawa
Affiliations

Detection of pyramidal tract lesions in amyotrophic lateral sclerosis with magnetization-transfer measurements

Y Kato et al. AJNR Am J Neuroradiol. 1997 Sep.

Abstract

Purpose: To determine the presence of small lesions in the pyramidal tract in patients with amyotrophic lateral sclerosis (ALS) by using magnetization-transfer (MT) measurements and MR imaging.

Methods: MT ratios (MTRs) were measured in the posterior limb of the internal capsule in nine patients with ALS and in nine healthy volunteers.

Results: The mean value of MTRs (%) in patients with ALS was 15.76 +/- 1.48, while that of the control subjects was 19.83 +/- 1.54. The difference was statistically significant.

Conclusions: MT measurements are useful for detecting abnormalities associated with degeneration of the pyramidal tract in patients with ALS.

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