The evaluation of some biochemical parameters in pyridoxine-treated calcium oxalate renal stone formers

Abstract

Several serum and urinary constitutents were evaluated in 13 calcium oxalate kidney stone formers in whom according to urinary vitamin B6 excretion sufficient vitamin B6 intake before the study was suggested. The influence of 28-day Pyridoxine (Spofa) supplementation (20 mg three times daily) on these biochemical parameters was searched. Pyridoxine supplementation was followed by a significant increment in the mean values of serum uric acid; the remaining serum constitutents did not change. Urinary calcium, phosphare, magnesium, sodium, potassium, and uric acid slightly increased, urinary oxalate excretion slightly fell; there was a high variability in the changes between the individuals. No changes in the mean values of clearance of endogenous creatinine, percentage of tubular reabsorption of phosphate and urinary zinc excretion were found. It is suggested that long-term studies are necessary to search the factors influencing successful stone prevention or stone recurrency in pyridoxine-treatment patients.