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. 1997 Sep;4(9):686-9.
doi: 10.1038/nsb0997-686.

Confirmation of the arginine-finger hypothesis for the GAP-stimulated GTP-hydrolysis reaction of Ras

M R Ahmadian, P Stege, K Scheffzek, A Wittinghofer

Confirmation of the arginine-finger hypothesis for the GAP-stimulated GTP-hydrolysis reaction of Ras

M R Ahmadian et al. Nat Struct Biol. 1997 Sep.

Abstract

RasGAPs supply a catalytic residue, termed the arginine finger,into the active site of Ras thereby stabilizing the transition state of the GTPase reaction and increasing the reaction rate by more than one thousand-fold, in good agreement with the structure of the Ras.RasGAP complex.

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