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. 1997;5(3):158-62.
doi: 10.1002/(SICI)1520-6823(1997)5:3<158::AID-ROI15>3.0.CO;2-2.

Oncogenic changes in murine lymphoid tumors induced by in utero exposure to ionizing radiation

K Lumniczky  1 , S Antal, E Unger, E J Hidvégi, G Sáfrány
Affiliations

Oncogenic changes in murine lymphoid tumors induced by in utero exposure to ionizing radiation

K Lumniczky et al. Radiat Oncol Investig. 1997.

Abstract

We have investigated the oncogenic alterations in murine lymphomas induced by in utero exposure to gamma-radiation. The expression of the myc oncogene increased in 23% of the tumors. Alterations in the expression of the ras oncogenes and in the p53 tumor suppressor gene were not characteristic. The p53 gene was mutated in a low percentage of the tumors (12%). Ras mutations were not detected. Loss of heterozygosity (LOH) at the p53 locus was found in 30% of the tumors, and LOH at the mts tumor suppressor gene was detected in 23% of lymphomas. Multiple oncogenic changes were infrequent in the investigated tumors. There were no essential differences in the frequency of carcinogenic alterations in spontaneous and gamma-radiation-induced lymphomas.

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