Synergistic activities of clarithromycin and pyrazinamide against Mycobacterium tuberculosis in human macrophages
- PMID: 9303411
- PMCID: PMC164062
- DOI: 10.1128/AAC.41.9.2035
Synergistic activities of clarithromycin and pyrazinamide against Mycobacterium tuberculosis in human macrophages
Abstract
The combination of clarithromycin and pyrazinamide was found to be synergistic against Mycobacterium tuberculosis in human macrophages. MICs were four- to eightfold lower for this combination than they were for either drug alone. Clarithromycin and rifampin, however, had only an additive effect.
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