[The role of mast cells in the infiltration phenomena in inflammation]

Abstract

On the model of the acute infectious peritonitis in rats it is shown that the previous osmotic depletion of the peritoneal mast cell population leads to the increased functional activity of neutrophils and decreased of monocytes of the inflammatory focus and blood. The results indicate that in the natural inflammatory conditions mast cells directly or indirectly inhibit neutrophils and stimulate monocytes, i.e. they are the modulators of leukocytic reaction.