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Review
. 1997 Jul-Aug;28(4):245-61.

[X-chromosome inactivation in mammalian ontogeny]

[Article in Russian]
V N Evdokimova, S A Nazarenko
  • PMID: 9304089
Review

[X-chromosome inactivation in mammalian ontogeny]

[Article in Russian]
V N Evdokimova et al. Ontogenez. 1997 Jul-Aug.

Abstract

This review is dedicated to a very interesting problem of developmental genetics: dose compensation of the X-chromosome genes in somatic cells of female mammals. A sequence of events related to X-chromosome inactivation during cell differentiation at the early embryonic stages, association of distributed X-chromosome heterochromatization with developmental pathologies, evolutionary origin of X-inactivation, and its relationship with genomic imprinting are considered.

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