doi: 10.1007/BF01953254.
Epidermal growth factor stimulates proliferation of rat hepatoma cells producing alpha-fetoprotein
- PMID: 93054
- DOI: 10.1007/BF01953254
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Epidermal growth factor stimulates proliferation of rat hepatoma cells producing alpha-fetoprotein
Experientia.
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Abstract
Epidermal growth factor stimulated both [3H]thymidine uptake and proliferation of rat AH66 hepatoma cells. However, the increase in cell number was not accompanied by a proportional increase in the levels of alpha-fetoprotein of the culture media. The effects of EGF on the cell proliferation were antagonized by N6,O2'-dibutyryl cAMP.
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