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. 1997 Aug;86(8):890-1.
doi: 10.1111/j.1651-2227.1997.tb08617.x.

Selective compartmentalization of gammadelta-T lymphocytes in human breastmilk

A Lindstrand  1 , L Smedman, G Gunnlaugsson, M Troye-Blomberg
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Selective compartmentalization of gammadelta-T lymphocytes in human breastmilk

A Lindstrand et al. Acta Paediatr. 1997 Aug.

Abstract

In human breastmilk, T lymphocytes with gammadelta-receptor (TCR) are more frequent than those with alphabeta-TCR, in comparison with peripheral blood. Differential representation has also been demonstrated for subpopulations of gammadelta-T cells. Reactivity was visualized with three monoclonal antibodies against Vdelta1, Vdelta2 and Vgamma2 on T cells from the breastmilk and peripheral blood of 12 women who had recently given birth. Confirming the results with Vdelta1, it was found that Vdelta1 (p < 0.01) and Vgamma2 (p < 0.05) but not Vdelta2 were overrepresented on T cells in milk as compared with blood. This selective compartmentalization seems to reflect the homing of certain cells to the mammary gland.

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Comment in

  • Human milk cells.
    Xanthou M. Xanthou M. Acta Paediatr. 1997 Dec;86(12):1288-90. doi: 10.1111/j.1651-2227.1997.tb14899.x. Acta Paediatr. 1997. PMID: 9475302 Review. No abstract available.

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