Review
[TNF]
[Article in
Japanese]
Affiliations
- PMID: 9309146
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Review
[TNF]
[Article in
Japanese]
Gan To Kagaku Ryoho.
1997 Sep.
Abstract
TNF exerts its biological activities through two distinct receptors of TNF-R55 and TNF-R75. Recent studies have identified TNF receptor-associated molecules, and intracellular signal transduction for apoptosis induced by TNF has been elucidated. Various TNF mutants with higher affinity to TNF-R55 and lower affinity to TNF-R75 are being clarified biogenetically. These mutants show lower adverse effect and higher antitumor activity. Furthermore, TNF gene transduction into lymphocytes and tumor cells shows a decrease in tumorigenicity and enhancement of host immunogenicity. This approach appears to be promising for cancer treatment.
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