Review
[CDK and MMP inhibitors]
[Article in
Japanese]
Affiliations
- PMID: 9309154
Item in Clipboard
Review
[CDK and MMP inhibitors]
[Article in
Japanese]
Gan To Kagaku Ryoho.
1997 Sep.
Abstract
CDK inhibitor, Butyrolactone I inhibited CDK1, 2 and 5 in CDKs. In syncronized human lung fibroblast WI38 cells, it inhibited G1/S transition by inhibiting the phosphorylation of RB protein and G2/M transition by inhibiting the phosphorylation of H1 histone. Also, it selectively inhibited the initiation of DNA replication. The MMP inhibitor, BE16627B, reversively inhibited metalloproteinases including MMPs. It showed the MMP-dependent inhibition of the growth and metastasis of human tumor cells in nude mice without any cytotoxicity and severe side effects. The MMP inhibitor, Marimastat, showed remarkable prolongation of the life span of patients with pancreatic tumors in clinical trials.
Similar articles
-
A novel matrix metalloproteinase inhibitor, FYK-1388 suppresses tumor growth, metastasis and angiogenesis by human fibrosarcoma cell line.Int J Oncol. 2003 Feb;22(2):281-8. Int J Oncol. 2003. PMID: 12527923
-
Matrix metalloproteinase (MMP) inhibition selectively decreases type II MMP activity in a murine model of pancreatic cancer.J Surg Res. 1999 Jan;81(1):65-8. doi: 10.1006/jsre.1998.5447. J Surg Res. 1999. PMID: 9889060
-
Inhibition of growth of human tumor cells in nude mice by a metalloproteinase inhibitor.Int J Cancer. 1994 Sep 1;58(5):730-5. doi: 10.1002/ijc.2910580518. Int J Cancer. 1994. PMID: 8077060
-
Chemical inhibitors of cyclin-dependent kinases.Prog Cell Cycle Res. 1995;1:351-63. doi: 10.1007/978-1-4615-1809-9_29. Prog Cell Cycle Res. 1995. PMID: 9552377 Review.
-
Preclinical and clinical studies of MMP inhibitors in cancer.Ann N Y Acad Sci. 1999 Jun 30;878:228-35. doi: 10.1111/j.1749-6632.1999.tb07688.x. Ann N Y Acad Sci. 1999. PMID: 10415734 Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous