Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1997 Aug 15;765(2):331-6.
doi: 10.1016/s0006-8993(97)00682-3.

Local opiate withdrawal in locus coeruleus in vivo

G Aston-Jones  1 , H Hirata, H Akaoka
Affiliations

Local opiate withdrawal in locus coeruleus in vivo

G Aston-Jones et al. Brain Res. .

Abstract

Hyperactivity of noradrenergic locus coeruleus (LC) neurons following withdrawal from chronic opiates has been implicated in the opiate withdrawal syndrome. Here, we report that local withdrawal induced in vivo by microinfusion of an opiate antagonist into the LC of morphine-dependent rats marginally, but significantly, activated LC neurons above the level obtained with local naloxone microinfusion in naive rats. This local withdrawal response contributes a significant fraction (approximately 19%) of the total LC hyperactivity induced by systemic naloxone.

PubMed Disclaimer

Publication types

LinkOut - more resources