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. 1997 Sep 1;196(1-2):219-29.
doi: 10.1016/s0378-1119(97)00230-8.

The chicken CCAAT/enhancer binding protein alpha gene. Cloning, characterisation and tissue distribution

C F Calkhoven  1 , S I Gringhuis, G Ab
Affiliations

The chicken CCAAT/enhancer binding protein alpha gene. Cloning, characterisation and tissue distribution

C F Calkhoven et al. Gene. .

Abstract

We present the cloning and sequencing of the gene encoding the chicken CCAAT/Enhancer Binding Protein alpha (cC/EBP alpha). The coding region and 1.5 kb of 5' flanking DNA from a CpG island. Comparison of the chicken C/EBP alpha sequence to the homologous proteins of other species reveals several evolutionary conserved regions. cC/EBP alpha mRNA expression is restricted to a subset of tissues with high expression in liver, lung and small intestine. Recombinant cC/EBP alpha binds to its cognate C/EBP binding site as a homodimer or as a heterodimer with the related cC/EBP beta/NF-M.

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