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Case Reports
. 1997 Oct;19(7):629-33.
doi: 10.1002/(sici)1097-0347(199710)19:7<629::aid-hed11>3.0.co;2-y.

Clinically aggressive metastasizing pleomorphic adenoma: report of two cases

J Klijanienko  1 , A K El-Naggar, V Servois, J Rodriguez, P Validire, P Vielh
Affiliations
Case Reports

Clinically aggressive metastasizing pleomorphic adenoma: report of two cases

J Klijanienko et al. Head Neck. 1997 Oct.

Abstract

Background: It has been suggested that metastasizing pleomorphic adenomas may represent unrecognized malignancy.

Methods: The cytologic and clinical characteristics of two metastasizing pleomorphic adenomas diagnosed by fine-needle sampling are reported.

Results: Both showed malignant evolution: the primary tumors arose from the palate and the parotid salivary glands, respectively. Metastases occurred simultaneously with local recurrence in the first patient and after a second local recurrence in the second patient. Both patients were treated by surgery and radiotherapy but died of disseminated disease 8 and 4 years after initial diagnosis. No histologic evidence of malignancy was observed on cytology smears or histology sections in either case.

Conclusion: Clinically, our cases support the hypothesis that metastasizing pleomorphic adenomas represent unrecognized malignancy, because the biologic course of two tumors led to unequivocally lethal outcome.

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