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Review
. 1997 Sep 26:826:1-6.
doi: 10.1111/j.1749-6632.1997.tb48456.x.

Cerebrovascular pathology in Alzheimer's disease: cause, effect or epiphenomenon?

V Hachinski  1 , D G Munoz
Affiliations
Review

Cerebrovascular pathology in Alzheimer's disease: cause, effect or epiphenomenon?

V Hachinski et al. Ann N Y Acad Sci. .

Abstract

Cerebrovascular pathology abounds in Alzheimer's disease. Changes in the endothelium, disruption of the blood-brain barrier and amyloid deposition in the cerebral blood vessels are almost universal in advanced cases. Do these changes represent the cause, the effect, or the consequences of a common pathogenesis of Alzheimer's disease? This volume addresses some of these issues by presenting new knowledge gained from a diversity of fields. Recognition of the mechanisms involved will open new possibilities for therapeutic trials.

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