Review
doi: 10.1016/s0955-0674(97)80114-7.
CEA adhesion molecules: multifunctional proteins with signal-regulatory properties
Affiliations
- PMID: 9330864
- PMCID: PMC7135799
- DOI: 10.1016/s0955-0674(97)80114-7
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Review
CEA adhesion molecules: multifunctional proteins with signal-regulatory properties
Curr Opin Cell Biol.
1997 Oct.
Abstract
The carcinoembryonic antigen family comprises a large number of complex molecules, several of which possess cell adhesion activities. The primordial adhesion molecules of this family are the cell-cell adhesion molecules (C-CAMs), which have been found to be multifunctional, signal-regulatory proteins. C-CAMs inhibit tumor growth, interact with calmodulin, protein tyrosine kinases and protein tyrosine phosphatases, and are subject to specific dimerization reactions. These new insights indicate that C-CAMs are important regulators of cellular functions.
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