Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 1997 Oct;9(5):616-26.
doi: 10.1016/s0955-0674(97)80114-7.

CEA adhesion molecules: multifunctional proteins with signal-regulatory properties

B Obrink  1
Affiliations
Review

CEA adhesion molecules: multifunctional proteins with signal-regulatory properties

B Obrink. Curr Opin Cell Biol. 1997 Oct.

Abstract

The carcinoembryonic antigen family comprises a large number of complex molecules, several of which possess cell adhesion activities. The primordial adhesion molecules of this family are the cell-cell adhesion molecules (C-CAMs), which have been found to be multifunctional, signal-regulatory proteins. C-CAMs inhibit tumor growth, interact with calmodulin, protein tyrosine kinases and protein tyrosine phosphatases, and are subject to specific dimerization reactions. These new insights indicate that C-CAMs are important regulators of cellular functions.

PubMed Disclaimer

References

    1. Gold P, Freedman SO. Specific carcinoembryonic antigens of the human digestive system. J Exp Med. 1965;122:467–481. - PMC - PubMed
    1. Thompson JA, Grunert F, Zimmermann W. The carcinoembryonic antigen gene family: molecular biology and clinical perspectives. J Clin Lab Anal. 1991;5:344–366. - PubMed
    1. Öbrink B. C-CAM (Cell-CAM 105) — a member of the growing immunoglobulin superfamily of cell adhesion proteins. Bioessays. 1991;13:227–234. - PubMed
    1. Stanners CP, Rojas M, Zhou H, Fuks A, Beauchemin N. The CEA family: a system in transitional evolution? Int J Biol Markers. 1992;7:137–142. - PubMed
    1. Nagel G, Grunert F. From genes to proteins: the nonspecific cross-reacting antigens. Tumour Biol. 1995;16:17–22. - PubMed

Publication types

Substances

LinkOut - more resources