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Review
. 1997 Oct;9(5):683-90.
doi: 10.1016/s0955-0674(97)80122-6.

Cadherins, catenins and APC protein: interplay between cytoskeletal complexes and signaling pathways

A I Barth  1 , I S Näthke, W J Nelson
Affiliations
Free article
Review

Cadherins, catenins and APC protein: interplay between cytoskeletal complexes and signaling pathways

A I Barth et al. Curr Opin Cell Biol. 1997 Oct.
Free article

Abstract

Cadherins play important roles in cell-cell adhesion during tissue differentiation. Cadherins are linked to the actin cytoskeleton by catenins (beta-catenin/armadillo, plakoglobin, and alpha-catenin). Recent results show that beta-catenin also binds to another cytoskeletal complex containing the adenomatous polyposis coli protein and microtubules, and interacts with several signaling pathways that include tyrosine kinases and phosphatases and Wnt/Wingless. Interplay between these cytoskeletal complexes and signaling pathways may regulate morphogenesis.

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