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. 1997 Oct;41(10):2289-91.
doi: 10.1128/AAC.41.10.2289.

Mutations in the gyrA and parC genes in fluoroquinolone-resistant clinical isolates of Pseudomonas aeruginosa

M Nakano  1 , T Deguchi, T Kawamura, M Yasuda, M Kimura, Y Okano, Y Kawada
Affiliations

Mutations in the gyrA and parC genes in fluoroquinolone-resistant clinical isolates of Pseudomonas aeruginosa

M Nakano et al. Antimicrob Agents Chemother. 1997 Oct.

Abstract

We determined partial sequences of the gyrA and parC genes of the fluoroquinolone-susceptible strain ATCC 27853 and 22 clinical isolates of Pseudomonas aeruginosa. While a single amino acid change in GyrA with or without a change in ParC was found in 14 isolates with decreased susceptibility to fluoroquinolones, 3 higher-level fluoroquinolone-resistant isolates had a double amino acid change in GyrA and a single amino acid change in ParC.

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References

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