Genetics of aging
- PMID: 9334291
- DOI: 10.1126/science.278.5337.407
Genetics of aging
Abstract
The role of genetics in determining life-span is complex and paradoxical. Although the heritability of life-span is relatively minor, some genetic variants significantly modify senescence of mammals and invertebrates, with both positive and negative impacts on age-related disorders and life-spans. In certain examples, the gene variants alter metabolic pathways, which could thereby mediate interactions with nutritional and other environmental factors that influence life-span. Given the relatively minor effect and variable penetrance of genetic risk factors that appear to affect survival and health at advanced ages, life-style and other environmental influences may profoundly modify outcomes of aging.
Comment in
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Presenilin interactions and Alzheimer's disease.Science. 1998 Jan 23;279(5350):463-5. doi: 10.1126/science.279.5350.459h. Science. 1998. PMID: 9454341 No abstract available.
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