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. 1997 Sep;14(6):723-8.
doi: 10.1023/a:1018521501289.

Anti-inflammatory activity of superoxide dismutase conjugated with sodium hyaluronate

K Sakurai  1 , K Miyazaki, Y Kodera, H Nishimura, M Shingu, Y Inada
Affiliations

Anti-inflammatory activity of superoxide dismutase conjugated with sodium hyaluronate

K Sakurai et al. Glycoconj J. 1997 Sep.

Abstract

Superoxide dismutase (SOD) from bovine erythrocytes was conjugated with sodium hyaluronate (HA) with a mean molecular weight of 10(6) to have greater anti-inflammatory activity in vivo. Amino groups of SOD were coupled with carboxyl groups in the hyaluronate molecule using 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide. The HA-SOD conjugate was composed of 1.5 mol of SOD molecule per 1 mol of hyaluronate on the average, and retained 70% of the activity of unmodified SOD. The conjugate was essentially non-immunogenic in mice, and exhibited much higher anti-inflammatory activities than HA or SOD in models of inflammatory diseases such as ischemic oedema of the foot-pad in mice, carrageenin-induced pleurisy and adjuvant arthritis in rats.

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