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. 1997 Oct;28(10):1948-50.
doi: 10.1161/01.str.28.10.1948.

Activated microglial cells are colocalized with perivascular deposits of amyloid-beta protein in Alzheimer's disease brain

T Uchihara  1 , H Akiyama, H Kondo, K Ikeda
Affiliations

Activated microglial cells are colocalized with perivascular deposits of amyloid-beta protein in Alzheimer's disease brain

T Uchihara et al. Stroke. 1997 Oct.

Abstract

Background and purpose: Microglial cells are present in the center of senile plaques (SPs) in Alzheimer's disease (AD) brain. Such a localization of microglial cells suggests that they are involved in the deposition or the clearance of amyloid-beta protein (A beta) in the brain. We examined their association with another type of parenchymal A beta deposit, which is termed the perivascular deposits of A beta (PA beta).

Methods: Thick sections from AD brain were stained with a three-color immunofluorescence method that labeled A beta, activated microglial cells, and vascular endothelial cells simultaneously.

Results: Three-dimensional observation under a laser scanning microscope confirmed that perivascular aggregates of activated microglial cells were colocalized with PA beta.

Conclusions: Microglia occur in association with both SPs and PA beta, suggesting that they play important roles in the metabolism of A beta in AD brain.

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