Review
doi: 10.1016/s1054-3589(08)60207-0.
Experimental models for evaluating enzyme induction potential of new drug candidates in animals and humans and a strategy for their use
Affiliations
- PMID: 9342178
- DOI: 10.1016/s1054-3589(08)60207-0
Item in Clipboard
Review
Experimental models for evaluating enzyme induction potential of new drug candidates in animals and humans and a strategy for their use
Adv Pharmacol.
1997.
Abstract
Experimental models that have application for evaluating enzyme induction potential have been described in order of increasing complexity. The main focus was on models that have had wide application thus far. However, many new models are currently being developed that may have future applications in evaluating enzyme induction potential. A strategy to evaluate the enzyme induction potential of drug candidates was outlined. This scheme uses a combination of new and established techniques to evaluate data in a stepwise manner that is appropriate to the drug's current stage of development.
Similar articles
-
Preclinical evaluation of drug-drug interaction potential: present status of the application of primary human hepatocytes in the evaluation of cytochrome P450 induction.Chem Biol Interact. 1997 Nov 6;107(1-2):5-16. doi: 10.1016/s0009-2797(97)00070-7. Chem Biol Interact. 1997. PMID: 9402946 Review.
-
Metabolism profiling, and cytochrome P450 inhibition & induction in drug discovery.Curr Top Med Chem. 2001 Nov;1(5):403-25. doi: 10.2174/1568026013395001. Curr Top Med Chem. 2001. PMID: 11899105 Review.
-
The time to move cytochrome p450 induction into mainstream pharmacology is long overdue.Drug Metab Dispos. 2007 Apr;35(4):697-8. doi: 10.1124/dmd.106.013284. Drug Metab Dispos. 2007. PMID: 17384203 No abstract available.
-
Screening of drug candidates for their drug--drug interaction potential.Curr Opin Chem Biol. 2001 Aug;5(4):396-401. doi: 10.1016/s1367-5931(00)00220-9. Curr Opin Chem Biol. 2001. PMID: 11470602 Review.
-
The maintenance of cytochrome P-450 in rat hepatocyte culture: some applications of liver cell cultures to the study of drug metabolism, toxicity and the induction of the P-450 system.Chem Biol Interact. 1990;74(1-2):1-31. doi: 10.1016/0009-2797(90)90055-r. Chem Biol Interact. 1990. PMID: 2182201 Review.