Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1997 Jul-Aug;37(4):443-8.
doi: 10.1051/rnd:19970405.

Comparison of vitamin C bioavailability after multiple or single oral dosing of different formulations in sheep

Affiliations
Free article
Comparative Study

Comparison of vitamin C bioavailability after multiple or single oral dosing of different formulations in sheep

M Hidiroglou et al. Reprod Nutr Dev. 1997 Jul-Aug.
Free article

Abstract

The purpose of this study was to compare the bioavailability of either multiple or single oral supplementation of different formulations of vitamin C and intra-duodenal supplementation of one form of vitamin C in sheep. Formulations used in the study were (1) ascorbic acid fine powder (AA); (2) ascorbic acid coated with ethyl cellulose (EC); (3) Rovimix STAY-C (SC); (4) sodium ascorbate (SA); (5) Rovimix C (RC). The bioavailability of vitamin C formulations was assessed by the changes in plasma ascorbic acid concentrations, area under the curve (AUC) and area under the curve above its basal concentration (AUCabove) values. There was no effect of single oral supplementation on bioavailability of vitamin C. Multiple dosing over a period of 28 days of oral supplementation of all five formulations resulted in higher AUCabove values. Furthermore, multiple oral supplementation of RC increased plasma concentrations of ascorbic acids and AUC values. Single intra-duodenal supplementation of ascorbic acid resulted in significantly higher AUC when compared with oral supplementation of the same vitamin C.

PubMed Disclaimer

Publication types

LinkOut - more resources