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. 1976 Jun 17;261(5561):558-60.
doi: 10.1038/261558a0.

Identification of an enzyme in platelet microsomes which generates thromboxane A2 from prostaglandin endoperoxides

P Needleman, S Moncada, S Bunting, J R Vane, M Hamberg, B Samuelsson

Identification of an enzyme in platelet microsomes which generates thromboxane A2 from prostaglandin endoperoxides

P Needleman et al. Nature. .

Abstract

The microsomal fraction of horse and human platelets contains an enzyme which converts prostaglandin cyclic endoperoxides (PGG2 or PGH2) to a substance which is much more potent in contracting strips of rabbit aorta. This substance has the same characteristics as thromboxane A2, and can be distinguished from other products of arachidonic acid metabolism by differential bioassay.

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