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. 1997 Nov;71(11):8856-9.
doi: 10.1128/JVI.71.11.8856-8859.1997.

Hepatitis C virus nonstructural region 5A protein is a potent transcriptional activator

N Kato  1 , K H Lan, S K Ono-Nita, Y Shiratori, M Omata
Affiliations

Hepatitis C virus nonstructural region 5A protein is a potent transcriptional activator

N Kato et al. J Virol. 1997 Nov.

Abstract

The hepatitis C virus (HCV) nonstructural region 5A (NS5A) protein, without its 146 amino-terminal amino acids and fused to the DNA-binding domain of GAL4, strongly activates transcription in yeast and human hepatoma cells. Transcriptional activation by the HCV NS5A protein may play a role in viral replication and hepatocarcinogenesis.

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