Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1997 Nov;71(11):8918-22.
doi: 10.1128/JVI.71.11.8918-8922.1997.

Human immunodeficiency virus type 2 envelope glycoprotein binds to CD8 as well as to CD4 molecules on human T cells

H Kaneko  1 , L P Neoh, N Takeda, H Akimoto, T Hishikawa, H Hashimoto, S Hirose, S Karaki, M Takiguchi, H Nakauchi, Y Kaneko, N Yamamoto, I Sekigawa
Affiliations

Human immunodeficiency virus type 2 envelope glycoprotein binds to CD8 as well as to CD4 molecules on human T cells

H Kaneko et al. J Virol. 1997 Nov.

Abstract

We report here that human immunodeficiency virus type 2 (HIV-2) envelope glycoprotein (gp105), but not HIV-1 gp120, can bind to CD8 molecules as well as to CD4 molecules on human T cells. This phenomenon may lead to differences in the life cycles of HIV-1 and HIV-2, and it may be related to the differences in disease manifestations of HIV-1 and HIV-2 infection, including longer survival of HIV-2-infected patients.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. J Immunol. 1981 Nov;127(5):2124-9 - PubMed
    1. Hybridoma. 1983;2(2):187-99 - PubMed
    1. Science. 1985 Jun 7;228(4704):1201-4 - PubMed
    1. Lancet. 1985 Dec 21-28;2(8469-70):1387-9 - PubMed
    1. J Immunol. 1986 Feb 15;136(4):1247-52 - PubMed

Publication types

MeSH terms

Substances