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. 1997 Nov;71(11):8918-22.
doi: 10.1128/JVI.71.11.8918-8922.1997.

Human immunodeficiency virus type 2 envelope glycoprotein binds to CD8 as well as to CD4 molecules on human T cells

H Kaneko  1 , L P Neoh, N Takeda, H Akimoto, T Hishikawa, H Hashimoto, S Hirose, S Karaki, M Takiguchi, H Nakauchi, Y Kaneko, N Yamamoto, I Sekigawa
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Human immunodeficiency virus type 2 envelope glycoprotein binds to CD8 as well as to CD4 molecules on human T cells

H Kaneko et al. J Virol. 1997 Nov.

Abstract

We report here that human immunodeficiency virus type 2 (HIV-2) envelope glycoprotein (gp105), but not HIV-1 gp120, can bind to CD8 molecules as well as to CD4 molecules on human T cells. This phenomenon may lead to differences in the life cycles of HIV-1 and HIV-2, and it may be related to the differences in disease manifestations of HIV-1 and HIV-2 infection, including longer survival of HIV-2-infected patients.

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