Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 1997 Oct 20;239(2):357-66.
doi: 10.1006/bbrc.1997.7409.

The role of calcium in the regulation of apoptosis

D J McConkey  1 , S Orrenius
Affiliations
Review

The role of calcium in the regulation of apoptosis

D J McConkey et al. Biochem Biophys Res Commun. .

Abstract

Apoptosis (programmed cell death) has gained widespread attention due to its roles in a variety of physiological and pathological processes, yet precisely how apoptosis is regulated by external and internal cues remains unclear. Work from our laboratories and others has implicated alterations in intracellular Ca2+ in apoptosis, and more recent work has defined particular biochemical processes that are targeted by Ca2+ in apoptotic cells. This review will summarize the role of Ca2+ in apoptosis within the context of what is known about the core components of the effector machinery for apoptosis.

PubMed Disclaimer

LinkOut - more resources