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Comparative Study
. 1976 Mar;4(3):347-9.
doi: 10.1016/0091-3057(76)90254-9.

Comparison in mice of the amnestic effects of cycloheximide and 6-hydroxydopamine in a one-trial passive avoidance task

T C Rainbow, J E Adler, L B Flexner
Comparative Study

Comparison in mice of the amnestic effects of cycloheximide and 6-hydroxydopamine in a one-trial passive avoidance task

T C Rainbow et al. Pharmacol Biochem Behav. 1976 Mar.

Abstract

To test further the hypothesis that cycloheximide (CXM)-induced amnesia is due in part to its effects on the central adrenergic system, a comparison was made in mice of the effects of the antibiotic and of 6-hydroxydopamine (6-OHDA) on memory of a one-trial passive avoidance task. Both drugs produced anmesia 24 hr after training but unlike CXM, 6-OHDA had no effect on memory 20 min after training.

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