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. 1997 Oct;24(7):677-83.
doi: 10.1016/s0969-8051(97)00078-4.

Fluorine-18-labeled fluorine gas for synthesis of tracer molecules

J Bergman  1 , O Solin
Affiliations

Fluorine-18-labeled fluorine gas for synthesis of tracer molecules

J Bergman et al. Nucl Med Biol. 1997 Oct.

Abstract

The aim of this work was to develop a method to produce 18F-labeled fluorine gas ([18F]F2) with high specific radioactivity (SA, radioactivity/mass-ratio). 18F-Labeled methyl fluoride ([18F]CH3F) was synthesized from [18F]F-aq and mixed with carrier F2 in an inert neon matrix. The constituents were atomized in an electric discharge, after which a rearrangement and 18F for 19F exchange took place. [18F]F2 with a specific radioactivity of up to 55 GBq/mumol is available for the labeling synthesis of tracers for positron emission tomography (PET).

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